Critically evaluate, in relation to the common law duty of care, the Essay - 2

Critically evaluate, in relation to the common law duty of care, the liability of employers for references - Essay Example This essay is going to analyse the provision of duty of care in tort law. Law and Duty of Care A tort can be defined as a wrongdoing or action upon which damages can be brought or in other terms it is referred to as an act or omission by the defendant, which causes damage to the claimant. The important task of undertaking business activities requires adherence to regulations and laws. Tort law recognises a provision known as duty of care whereby the action of a person that amounts to negligence is punishable by the tort law. Duty of care emphasizes on the responsibility on the part of both or more parties as it relates to the involvement in a specific case or scenario. The principle of duty of care arises from previous cases as it relates to the tort law (Steele, 2007). For instance, the case of Anns v Merton LBC [1978] AC 728 (HL) whereby the judge Lord Wilberforce held that a two stage approach would be used in determining the care of duty. In this case the issue of prima facie in determining the relationship between claimant and defendant while the second approach focused on the scope of duty. Future cases in relation to the tort law, other approaches emerged in the determination of duty of care (Harpwood, 2000). The duty of care can also be exercised within the job industry since it causes a lot of problems for employers and employees. In the process of handing out references for current and former employees, duty of care should be exercised. Issues dealing with reference should be handled in a proper manner since misrepresentation of the employee or client results in tort. For instance if a former employer or institution affiliated to a specific person presents information such as misleading reference without proper notification to the employee then a tort has occurred (Koziol, 2009). In this essay we are going to look into such scenarios in relation to the University of Sussex and its current or former students. The University is large institution with a large student population and more frequently the university receives request to have the institution hand out references (Best, 2007). When references are handed out the university owes the third party a duty of care regarding the reference issued out on the former or current students. The University has to exercise high standards of professionalism and ensure that the duty of care is handled properly when it comes to handing out references. The issues that need to be looked into from a legal standpoint include the misstatement or misrepresentation. References handed out onto potential employers must not be inaccurate or misleading. Therefore the University of Sussex has to exercise care in handing out references since it is against the law to misrepresent information concerning current of former students (Magnus, 2004). A student enrolled in the University of Sussex enters into a contract with the university to undertake certain courses for a given period of time. This contract is subject to terms agreed in the contract and upon graduation the University can refer its students to potential employers (Steele, 2007). However, the University has to exercise care in the provision of information concerning its students. For instance, if the university refers a student to an employer through misrepresenting reference then the university can be sued under tort law for negligent misrepresentation. The University should understand the provision on duty of care with

A movie review of the film The Insider Essay Example | Topics and Well Written Essays - 1500 words

A movie review of the film The Insider - Essay Example The film revolves around two people: Wigand, who was recently fired from a tobacco corporation, and Bergman, a veteran reporter in search of a story. The bombshell that Wigand holds in his possession is the information that Chief Executive Officers of tobacco corporations – The Big Seven – had known all along that tobacco was addictive but had concealed this information from the public. From there, the story unfolded masterfully – telling in gripping fashion how the influences of money and the legal system bore down on Wigand and Bergman, all in order to suppress the truth. Wigand was even the subject of extreme character assassination and despite his attempts to live a quiet life as a professor, was always followed by the story he chose to tell. He became the subject of death threats, the FBI was on his trail, his personal life was in disarray. In the meantime, a bigger context was unfolding. There was a lawsuit poised to be filed against the Big Seven in order to recover what the State paid in medical expenses to treat tobacco-related illnesses. Two legal concepts then emerged from the movie. The first one is the concept of tortuous interference – which basically means that if two parties have an agreement, and a third party induces a party privy to and bound by that agreement to break that agreement, that third party may be made liable for damages. That legal concept is used in connect to the confidential agreement, which is the second legal concept featured in this movie. In the film, Wigand was bound by an iron-clad confidentiality agreement that he was made to sign with his former company. The movie then forces its viewers to reflect: are there limits to a confidentiality agreement? What happens when a confidentiality agreement comes into conflict with public welfare, public health, or even simply the right of the public to know? It is important to situate the movie against the larger social backdrop on which it operates. The m ovie came out in the late 1990’s – a period in history when tobacco politics had reached a crucial juncture. It was at this period that the impunity of the tobacco firms to lawsuit had ended and for the first time, they were being held liable for the addictive consequences of cigarettes. How dangerous really is tobacco? As early as 1964, the U.S. Surgeon General had come out with a landmark report that spoke of the dangers of smoking on one’s health and issued a categorical statement against its use and its spread. In an article, it was stated that: Each year three million people around the world die from tobacco-related illnesses. In the US, tobacco kills more than 400,000 people each year, and medical care for tobacco-related illnesses costs $50 billion annually. The World Health Organization projects that the yearly death toll from tobacco will rise to 10 million by the 2020swith seven million of those deaths striking economically poor countries. Of the one m illion US teens hooked each year on cigarettes, one-third or more will eventually die from tobacco-related illnesses. If current trends continue, over 200 million of today's children and teenagers around the world will lose their lives to this addictive product. (InFact: 1997) Despite these findings, the tobacco corporations have won every single legal battle against attempts to hold them accountable for putting public health in jeopardy. It is said that Philip Morris and other tobacco corporati

Behaviour of Termites: Breeding and Effects of Repellents

Behaviour of Termites: Breeding and Effects of Repellents Introduction and Review of Literature General biology of termite Termites are social insects that live in colonies, which, in turn, function because the complementary roles played by the different caste. In United States, subterranean termites, Coptotermes spp. and Reticulitermes spp. are the most destructive and cause substantial economic damage to buildings/structures (Su Scheffrahn 1990). A population of subterranean termites is comprised of distinct colonies. Colonies may occupy underground networks that link several foraging sites (Thorne Breish 2001). Termite foraging behavior The nutritional ecology of termites has played a significant role in shaping their evolution and ecology organization (Thorne, 1999). To understand colony structure and the organization of foraging termites, it has been necessary to map both nest and feeding sites, frequently using behavioral assays of aggression to ascertain the colony affinity of a given nest or group of workers occupying a food source (Long Thorne 2006). Also, dye indicators and mark release recapture studies have been developed to attempt to census colonies, determine colony boundaries, and plot the distribution of foragers and other spatial aspects of resource use (Su et al. 1984, Forschler Townsend 1996, Thorne et al. 1996, Abdul Hafiz et al. 2007). Studies of termite foraging range generally offer statistic description of colony nest and satellite sub nest distribution and sometimes reveal the temporal dynamics of foraging range expansion and territorially, similar to what has been described in ants. Colony structure and the spatial organization of foraging in termites are, nevertheless, poorly understood in comparison to other social insects. The cryptic nesting and foraging habits of subterranean termites have hindered our understanding of many important features of their population biology, especially the distinctness of colonies and the breeding system within colonies. Their cryptic foraging and nesting habits, many features of subterranean termite biology have been difficult to study by using the traditional methods of field investigation. The main obstacle has been a lack of practical methods for delineating large numbers of colonies (Long Thorne 2006). Termite control Chemical and physical barriers to prevent them from reaching wood construction are two basic methods that have been used to control termites. Currently, insecticides used for termite control can be categorized into three groups, organochlorine, cyclodiens, which are being phased out of use because of potential damage to the environment and human health; pyrethroids, which considered not effective because of their repellency and short residual life in soil; and new termiticides that are considered as non repellent and slow acting termiticide (Potter and Hillary 2003). Remedial control is extremely difficult with acutely toxic chemicals because termites avoid area with dead termites, preventing any further contact with the toxicant. For the Formosan subterranean termites, remedial control using slow-acting toxic baits is are more acceptable method than the use of acutely toxic insecticides. Sub lethal insecticide exposure may be expected to influence insect behavior because most insect icides attack the nervous system resulting in detection by insects, distruption of physiological processes, and behavioral resistance (Haynes 1988, Silverman and Bieman 1993). The purpose of applying insecticides to soil proximal to a structures foundation of a continuous insecticide barrier in soils under and around the structure (Kamble, 1991). This barrier may be created by using either pre or post construction techniques. Post construction insecticide application technique include void treatments, soils trenching, sub slab injections, and soil rodding application. Chemical and physical barriers to prevent them from reaching wood construction are two basic methods that have been used to control termites (Abdul Hafiz et al. 2007). Remedial control is extremely difficult with acutely toxic chemicals because termites avoid area with dead termites, preventing any further contact with the toxicant. Sub lethal insecticide exposure may be expected to influence insect behavior because most insecticides attack the nervous system resulting in detection by insects, disruptions of physiological processes, and behavioral resistance (Haynes Baker 1988, Silverman Bi eman 1993) Non repellent termiticide Termiticide that do not repel termites from penetrating into treated soil but rather successfully kill them were recently registered in the United States (Kard 2003) and other parts of the world. They have become popular alternatives to conventional repellent soil-poisoning agents (Shelton and Grace 2003). Nonrepellent termiticides have been shown to be effective for the elimination of termite infestations when applied around the exterior perimeter of the building (Potter Hillary 2001) New generations of termiticides which contain imidacloprid (Premise ®), fipronil (Termidor ®) and indoxacarb, chlorfenapyr (Phantom ®), Chlorantraniliprole are used as soil-applied or by direct injection in the colony, posed lethal effects to subterranean termite (Osbrink Lax 2003; Kamble Davis, 2005; Hu et al., 2005; Spomer et al.,2009). The advantages of these new termiticides are slow-acting and non-repellent. Thus, termites cannot detect these termiticides when applied in to the soil or when used on filter paper in the laboratory. The transfer effect of imidacloprid, fipronil and indoxacarb among termite workers was studied by researchers and results showed that the termites were able to transfer the termiticides from the treated termites (donors) to the untreated termites (recipients) (Kard 2003, Thorne and Berisch 2001, Vargo Parman 2004, Tomalski and Vargo 2005, Hu et al. 2005, Shelton Grace 2006; Spomer et al.,2009). Termite baiting Baiting for suppression or elimination of subterranean termites is not a new idea. The ultimate goal of termite baits is to eliminate termites from structure (Su 1994, Su et al. 2000). Recently, hexaflumuron baits have successfully been applied to control the field colonies of Coptotermes spp. and Reticulitermes spp. (Su 1994, Su et al. 2000). At the same time Nouviflumuron also have been widely used in termite baiting. In laboratory trials in which R. flavipes were fed radiolabeled noviflumuron or hexaflumuron, noviflumuron demonstrated significantly faster speed of action, greater potency, and nearly 4-fold slower clearance from termites compared with that of hexaflumuron (Sheets et al. 2000; Karr et al. 2004, Spomer Kamble, 2006). Primer pheromones (Wilson Bossert, 1963) are chemical messengers that can be passed among individuals, thereby triggering a physiological response in a recipient. In termites, JH is one such primer pheromone (Henderson 1996); it includes presoldiers differentiation from workers at excessively high titer. The differentiation of the soldier caste, a development end point, in respond to JH is indirect in maintaining immature features in all other non social insects (Henderson, 1996). In the last decade there has been a dramatic increase in the research on and the development of bait systems for termite management. The increasing availability of bait systems for the control of active termite infestations is already significantly affecting termite management practices in many part of the world. There is even discussion of using such system as standalone measures for the long- term protection of a structure (Su et al. 2001; Grace et al. 1996). Even though these important and remarkable trends, baiting is developing technology, and many more changes to existing bait technology can be expected (Potter 1997). The bait matrices containing hexaflumuron, a chitin synthesis inhibitor, were most effective in reducing or eliminating foraging populations of Coptotermes formasanus Shiraki and Reticulitermes flavipes Kollar (Su Scheffrahn, 1996, Su, 1994). Molecular genetic marker The application of molecular genetic markers to the field populations of subterranean termite provides a powerful way to discriminate among large numbers of colonies be identified and distinguished from each other. The application of molecular genetic marker to field populations of subterranean termites provides a powerful way to discriminate among large numbers of conspecific colonies in a population as well as to determine colony breeding structure (Husseneder et.al. 2003) Genetic markers provide the most powerful means for delineating the boundaries of colonies and for determining colony affiliation for groups of foraging workers (Thorne et al.1999, Vargo 2003a,b). Microsatellite markers, with their co-dominant nature and high variability, are especially useful for investigation of colony distinctness (Vargo 2003b). Genetic markers are also the most practical way to determine colony breeding structure (Thorne et al.1999, Ross 2001), and there have been a growing number of genetic studies of breeding systems in termites (Luykx 1993, Husseneder et al. 1997, 1999, Husseneder Grace 2001a, 2001b, Vargo et al. 2003), including some on Reticulitermes spp. (Cle ´ment 1986, Reilly 1987, Jenkins et al. 2002, Bulmer et al. 2001, Vargo 2003b). The most detailed studies to date of the eastern subterranean termite, R. flavipes, are those of Reilly (1987) using allozymes, Bulmer et al. (2001) using allozymes and mitochondrial DNA haplotype data, and Vargo (2003a,b) using microsatellites and mitochondrial DNA sequence data. These studies have revealed variation in colony social organization in R. flavipes from very highly inbred colonies in Tennessee (Reilly 1987), to a mixture of approximately one third simple families and two thirds inbred colonies headed by many neotenic reproductives in Massachusetts (Bu lmer et al. 2001), to three fourths simple families and one fourth inbred families with only a few neotenics in North Carolina (Vargo 2003b). The above studies were conducted in natural areas, and there are no comparable studies performed to date in urban areas around buildings. Colony social organization in R. flavipes may vary in response to local ecological conditions (Bulmer et al. 2001), raising the possibility that for a given geographic area, colonies in urban habitats may differ in their social organization from those in natural habitats. In a study of Reticulitermes Hesperus Banks in southern California, Haagsma and Rust (1995) found differences in colony size, foraging activity, and body weight between colonies in natural and urban habitats. In addition to providing a powerful way to determine colony distinctness and to infer colony breeding structure in subterranean termites, molecular genetic markers are useful for applied studies, such as tracking colonies over time after exposure to an insecticide treatment and determining whether termites that reappear after treatment are part of the originally treated colony or are from a neighboring untreated colony that has moved into the area (Husseneder et al. 2003). Such studies are critical in the evaluation of management practices that target septic colonies and aim to eliminate them or greatly suppress their populations. Genetic/breeding structure population Colony fusion For social organisms, genetic structure assumes additional significant not only for the evaluation of social behavior, but also for the evolution of multiple queen societies, reproductive skew, sex ratio conflict, conflict over growth versus reproduction. Colony fusion has long been a suspected mechanism generating unusual colony genetic structure in termites. Colony genetic structure, reported a lack of genetic differentiation between colonies of Reticulitermes grasseiacross some regions of France and Spain. Together with this genetic data, a lack of distinct nest mate discrimination in laboratory trials (Clement 1986) suggested that colony fusion was widespread in some populations. Although recent studies have failed to corroborate these earlier descriptions of widespread colony fusion in this species (DeHeer et al. 2005), Clements work raised considerable awareness about colony fusion for those working on other subterranean termites. In introduced populations of Coptotermes formos anus, inter-colony aggression is often found to be weak or variable (Husseneder and Grace 2001a, Cornelius Osbrink, 2003) and one mark-release-recapture study described patterns consistent with a colony fusion event (Su and Scheffrahn, 1988). Nevertheless, genetic evidence for colony fusion in this species has remained elusive in spite of the relatively large numbers of colonies which have been assayed (Vargo et al., 2003, 2006; Husseneder et al., 2005). For Reticulitermes flavipes many experimental results have suggested the possibility that colony boundaries were porous. Laboratory agonism studies (Grace 1996, Polizzi and Forschler 1998, 1999, Bulmer and Traniello 2002, Fisher and Gold, 2003) and field surveys of molecular diversity (Jenkins et al. 2002, Bulmer et al. 2001) both suggested that individuals originating from different colonies may not distinguish between nestmates and non-nestmates, and consequently share the same nests or tunnel systems. However, in contrast to other species of subterranean termites these findings in R. flavipes have been confirmed via more direct assessments of colony fusion (Fisher et al. 2004), including one molecular study that provided a time course of colony genotypes before and after merger (DeHeer and Vargo 2004). Such fused colonies also appear to occur in other groups of termites. The relatedness hypothesis indicates that fused colonies are preferentially formed between groups of related termites because any costs associated with fusion are reduced when relatedness remains high in these colonies. This argument necessarily assumes that such colonies experience some general benefits to increasing their size (Costa and Ross, 2003). The genetic diversity hypothesis posits that increased genetic diversity provides sufficient group-level benefits to offset the costs of decreased relatedness within colonies. The specific benefits of increased genetic diversity could include the same types of benefits hypothesized to occur elsewhere (Schmid-Hempel and Crozier, 1999), in addition to the potential benefit that could result from a reduction in inbreeding. Simple family extend family Subterranean termite colony such as Coptotermes formosanus, generally begin as simple families headed by two primary (alate derived) reproductives that pair after mating (Tamashiro et al. 1987, Raina et al. 2003). As time goes by, the primary king and/or queen will be replaced by varying numbers of neotenics (non alate derived reproductives) from within colony; where this replacement leads to extended families with different degrees of inbreeding depending on the number of reproductives and number of generation of inbreeding (Thorne et.al 1999, Bulmer et al. 2001, Vargo et al. 2006, Husseneder et al. 2007) Bioinformatics/ Computational Molecular Biology Biological database is a large, organized body of persistent data, usually associated with computerized software designed to update, query, and retrieve components of the data stored within the system. A simple database can be a single file containing many records, each of which includes the same set of information (Lewis et al. 1995). For example, a record associated with a nucleotide sequence database typically contains information such as contact name, the input sequence with a description of the type of molecule, the scientific name of the source organism from which it was isolated, and often, literature citations associated with the sequence. The term of Bioinformatics meaning the application of information technology to the field of molecular biology. Bioinformatics currently contains the creation and advancement of databases, algorithms, computational and statistical techniques, and theory to solve formal and practical problems arising from the management and analysis of biological data (Hogeweg1980). Over the past few decades rapid developments in genomic and other molecular research technologies and developments in information technologies have combined to produce a tremendous amount of information related to molecular biology. It is the name given to these mathematical and computing approaches used to glean understanding of biological processes. Common activities in bioinformatics include mapping and analyzing DNA and protein sequences, aligning different DNA and protein sequences to compare them and creating and viewing 3-D models of protein structures (Huang 2004) Bioinformatics focus on developing and applying computationally intensive techniques (data mining, machine learning algorithms, and visualization) to achieve this goal. Major research efforts in the field include sequence alignment, gene finding, genome assembly, protein structure alignment, protein structure prediction, prediction of gene expression and protein-protein interactions, genome-wide association studies and the modeling of evolution (Huang 2004). In the application of molecular ecology studies of termites, mitochondrial genes were used for taxonomy purpose in termites (Cameron Whitting, 2007). Thus, the whole mitochondrial genome can be used to predict useful regions for further investigation in the multiple alignments methods application. Multiple alignments are the key starting point for prediction of protein secondary structure, residue accessibility, and the identification of residues important for specificity. Multiple alignments can provide the basis for the most sensitive sequence searching algorithms (Barton Sternberg, 1990). Furthermore, methods in multiple alignments affective analysis of a well-constructed multiple alignments can provide important clues about which residues in the protein are important for stabilizing the second and tertiary structure of the protein (Altschul et al. 1997) ClustalW will calculates the best match for the selected sequences, and lines them up so that the identities, similarities and differences can be seen and will provide a better quality for sequences (Thomson et al. 1994). Meanwhile, T-Cofee application is better to overcome with some of the problems that standard hierarchical method s have in aligning sequences of very different length or that share only local region similarity (Notredame et al. 2000). The program works by building a library of pairwise alignments for the sequence interest. Furthermore, T coffee has been adapted to include structural alignment and alignments from threading algorithms since it can work from pairwise alignments that originate from any source (Notredame et al. 2000). In addition, the program PSI-BLAST searches database with a single sequence, any high-scoring sequences that are found are built into a multiple alignment, and this multiple alignment is then used to derive a search profile for subsequent s earch of the database. This process is repeated until no new sequences are added to profile, or a specific number of iteration have been performed (Jones 1999). Research Objectives To test non-repellent termiticide model assay for their ability to induce detectable molecular changes in worker termites e. g., hemolymph proteins their corresponding genes. To infer the colony social organization of R. flavipes in urban habitat based on colony and population genetic structure and to compare this social organization in nearby natural habitat, To track the foraging locations of a large number of Reticulitermes colonies from natural forest (Wilderness Park) over the course of three field seasons using previously developed microsatellites by Vargo (2000). To analyze colony and population genetic structure/breeding system in natural and urban regions in order to determine the prevalence of neotenic reproduction and improve our understanding of the factors facilitating the spread of subterranean termites to new urban areas To determine the termite colony either a simple colony or extended colony using molecular ecology methods and also to determine if the colony undergo any kind of colony fusion To delineate the genetic structure of swarm aggregations of alates in order to infer potential mechanisms leading to inbreeding avoidance that do not require kin recognition. To utilize bioinformatic/molecular computational biology application tools to analyzing data at molecular level using BLAST, Clustal X, TCofee for sequencing analysis, pairwise/multiple alignment to study colony breeding structure of R.flavipes MATERIALS AND METHODS Termite Collection Sampling Reticulitermes flavipes, the Eastern subterranean termite, will be collected from locations within Wilderness Park Recreational Area, Lincoln; NE. Twenty workers will be sampled in each collection point located every 20 m along two intersection transects. The termites will be maintained on moistened corrugated cardboard and only 3-5th instar worker termites will be used for the study. Detection of fused colonies In order to detect colonies that had undergone fusion, collections of termites from large numbers of established colonies of R. flavipes will be collected between May 2009 and October 2011. At each location, minimum of 20 adult workers in 95%ethanol from multiple feeding sites, and mapped the locations of these feeding sites relative to one another using compass and measuring tape (DeHeer and Vargo, 2004). Samples will be stored in alcohol at 480C until DNAisolations could be performed. Microsatellite genotyping (Fusion Inbreeding) Using the Puregene DNA purification kit (Gentra systems, Minnepolis MN, www.gentra.com), genomic DNA will be isolated from each of 20 whole worker bodies from each of the feeding sites. At the location, minimum of 20 adult workers in 95% ethanol from multiple feeding sites will be collected, and mapped the locations of these feeding sites, and the locations of these feeding sites will be mapped relative to one another using compass and measuring tape. Each genotype individual termites at six different microsatellite loci : Rf1-3, Rf21-1 and Rf24-2 from Vargo (2000) and Rs15, Rs76, and Rs78 from Dronnet et al. (2004). PCR reactions will be setup in 96oC. Well plates in 5ul reaction mixtures containing 1X PCR buffer (Eppendorf), 2mM MgCl2, 0.2 mM of each dNTP, 0.2 U Taq polymerase (Eppendorf), 0.4 pmol of forward primer. Forward primers will be labeled with IRD 700 fluorescent dye (LI-COR), and samples were run on Li-Cor 4200L automated sequencer. Gel image will scored manually on Adobe Photoshop 7.0 by comparison to a size ladder. Colony affiliations To determine colony affiliation of the collection points, methods of other studies will be followed. Testing all pairs of collection points within each species for genotypic differentiation by means of a permutation test by using the program FSTAT (Goudet 2001). Pairs of collection points that will be significantly differentiated will be grouped into the same colony Morphology Scanning electron microscopic pictures (coronal and profile views) will made of the heads for each species) and will be studied using a binocular microscope to evaluate the profile of the post clypeus. Colour of the tibia of reproductives will be noted because this feature is an informative morphological indicator in association with the postclypeus profile. Genetic Data Analysis/ Simple or Extend Colony (Breeding Structure) The collection points will be analyzed to determine belonged to the same colony. The genotypic frequencies between all pairs of collection points by means of a log-likehood (G) based test of differentiation using the program GENEPOP on the Web (Raymond Rousset 1995; http://genepop.curtin.edu.au/). The overall significance will be determined via Fishers combined probability test. G-test analysis will be performed with collection points over the large scale with multiple collection points within the extensively sampled sites and finally among the colonies from each population to verify genetic differences will be used. Colonies will be classified as simple families when workers had genotypes consistent with being the direct offspring of one pair of reproductives and when the observed frequencies of the genotypes did not differ significantly from those expected under Mendelian segregation of alleles from two parents. Significance will be determines by a G-twst (P Colonies will be classified as extended families when the genotype distributions within colonies were not consistent with being produced by a single pair of reproductives (e.g more than four genotypes at a locus or three or more homozygote genotypes) or genotypes frequencies deviated significantly from those expected in simple families. Genetic relatedness among workers will be estimated for each colony and averaged over colonies for the same site will be using the computer program RELATEDNESS 5.00 (Queller Goodnight 1989) Inbreeding-adjusted estimate of relatedness r* that better reflects the number of reproductive presents in each colony by using Pamilo (1985) formula R*= r- [ 2FIT /(1+FIT)]/ [1-2FIT/(1+FIT)] I,C,T representing different colonies The breeding system and genetic differentiation among colonies will be investigated with hierarchial F statistics, assuming the infinite allele model and with individuals nested in colonies. The hierarchical analysis will be performed with F-stat program. It will be investigated whether there will be isolation by distance (a positive correlation between genetic differentiation and geographical distance) by calculating Fst between pairs of collection points within large colonies using the programe FSTAT 2.9.3.2 and by testing the significance of correlation between FST/(1-FST) and logarithm of geographical distances with MANTEL test (Mantel 1967). Computer program GENEPOP, with 10 000 permutations and the Mantel correlation coefficient r can be obtained with MANTEL (http://life.bio.sunysb.edu/morph/soft-mult.html) Estimating Colony Foraging Area Termite collected at a sampling point will considered to be affliated with a given colony if Fct, which measured genetic differentiation between collection points, will not significantly different from zero (i.e., 95% confidence interval did not overlap with zero. Fct will be measured between all possible combinations of collection points pair at each site. Variation in mitochondrial DNA markers will be provided additional support for colony designation (Bulmer et al. 2001). The maximum linear distance between collection points affiliated with the same colony will be used to estimate foraging range. For colonies that will be composed of three or more collection points (n+4), will be estimated the area encompassed by non intersecting lines drawn between collection points and adjusted so it did not overlap with neighboring collection points affiliated with different colonies. Swarming trap The swarm aggregation of alates will be collected alive with light traps. The traps consisted of buckets with a battery operated black light attached to attract the alates. Flight Observation Sticky trap will be used to monitor the dispersal flights of these species, which, in hindsight, may help explain some of the differences in how they are genetically structured. In addition their emergence and landing location. Sex ratio Sex ratio in swarm aggregations were tested for significant deviation from 1:1 using Binomial tests. Swarm aggregations were tested for significant genotypic differentiation with log likehood G Statistics using FSTAT 2.9.3.2 Bioassay Genetic mutation/change after being exposed to non repellent termiticide The concentrations were 0.001, 1.00, 10,100 and 1000 ppm for fipronil, imidacloprid and indoxacarb. In addition, distilled water was used as control for each termiticide. The method used for treatment was described by Hu (2005). Five kilograms of soil were collected from the site of the subterranean termite C. gestroi colony. The soil was then oven-dried. One kilogram for each termiticide was sieved and subsequently divided into six parts. The soil was placed in 100g increments into self-sealing plastic bags for treatment. Ten milliliters of the five concentrations of, fipronil, imidacloprid and indoxacarb will be added to the 100 g bag of soil for testing. The bags were sealed and allowed to mix thoroughly. The soil will be removed from the bags and placed in plastic bags (12 by 115 cm). The termiticide-treated soil was air-dried in a hood for ten days to allow solvents in the formulation to evaporate. Treatments were replicated three times using new stock solutions for each replicate. Bioassay design: Bioassay tubes designed by Su et al. (1995) will be used to investigate termite penetration in various thicknesses of termiticide-treated soil (Figure1). At time of testing, dried treated soil will be removed from the hood, placed into plastic bags and 10 ml of water was pipetted into the bags to obtain 10% moisture content. Three (3 cm) wooden applicator sticks were placed at the bottom of the glass test tube (2 by 15 cm), and 7% non-nutrient agar was inserted into the test tube until it rested on the wooden sticks. Oven-dried and sieved soil will be placed into plastic bags and moistened to concentrations of 10% (10ml /100g) to serve as untreated sand in the test designs. A 0.0, 1.0, 3.0, 5.0, or 10cm layer of termiticide-treated soil was centered between two layers of untreated soil (Figure.1). A glass funnel will be used to place the soil in the test tube and a scintillation vial (10ml) attached to the shank of a screwdriver was used to lightly and level the layers of soil. A 5 cm segment of termiticides-treated soil and a 5 cm segment of untreated soil served as control. Additionally, layers of untreated soil at various thicknesses in the bioassay tube will be served as control. The soil segment will be capped with a 1.0 cm core of agar and a 4cm by 4 cm portion of paper towel folded placed on the top of the tube. Eighty C. gestroi workers and five soldiers (20:1) were placed in each test tube to simulate normal termite activity and prevent overcrowding. A piece of aluminum foil will be placed over the top and end of each tube, and will be covered with black plastic container to allow for darkness and prevent desiccation of the termites. Bioassay tubes will be kept at 29 ±1 °C. The experiment was a 6 (concentrations) x 3 (replicates) x 5 (soil thickness) factorial design with concentration and thickness as the main effects. Test tubes will be held vertically in test tube racks with termites at the top of the tube. Observations will be made daily up to one week for the number of worker termite mortality, vertical distance of treated soil penetrated by termites and percentage of penetration into treated soil. The percentage of termite mortality and soil penetration data were subjected to arc-sine transformation before analysis of variance and means were separated with Tukey HSD. Then percentage of penetration into treated soil and the percentage of mortality were analyzed with analysis of variances (ANOVA). Also the percentage of surviving termites located at the bottom of the bioassay unit was analyzed. DNA will be isolated from dead termite to b

Capital Punishment Essay - Death Penalty and the Clash of Moral Ideolog

The Death Penalty and the Clash of Moral Ideologies      Ã‚     "Capital punishment is a term which indicates muddled thinking." George Bernard Shaw  Ã‚  Ã‚  Ã‚  Ã‚   The "muddled thinking" that Shaw speaks of is the thinking that perpetuates the controversy over capital punishment in the United States today.   The impractical concurrence of a theoretical, moral argument and definite, legal application has left all sides in this controversy dissatisfied with the ultimate handling of the issue.   There are legitimate ethical and empirical considerations that stand on both the side that favors and on the side that opposes the death penalty.   The general incompatibility of these considerations renders them irreconcilable.   It is within this condition of irreconcilability that the government must initiate and implement its policies regarding capital punishment.   This fixed condition has led to the necessity for and creation of comprises between both sites of this debate, attempting to synthesize the considerations of the t wo. The contentious issue of the capital punishment was rekindled in the 1970s when, in 1976, the Supreme reinstated the practice after a four-year hiatus.   The arguments that comprise much of the legal debate on the issue stem from the eighth and fourteenth amendments to the United States Constitution.   The eighth reads, "Excessive bail shall not be required, nor excessive fines imposed, nor cruel and unusual punishments inflicted." 1       The final clause of the first section of the fourteenth amendment explains, "nor shall any state deprive any person of life, liberty, or property, without due process of law; nor deny to any person within its jurisdiction the equal protection of the laws." 2     The 1976 ruling of Gregg v.... ... sides, regardless of personal conviction.   The inherent incompatibility of the arguments prevents any solution from meeting the expectations and satisfying the moral obligations of all parties.   This paradox leads to the need for compromise, in place of reconciliation, in death penalty legislation.   The status quo of the American legal system allows legislators to weigh the considerations of each side and come to some practical conclusion for the impractical clash of moral ideologies.    1  Ã‚  Ã‚   "Amendment VIII".   Constitution of the United States. 2  Ã‚  Ã‚   "Amendment XIV".   Constitution of the United States. 3   Gregg v. Georgia, 428 U.S. 153 (1976). United States Supreme Court.   Pp. 168-187. 4  Ã‚   "Leviticus".   The Soncino Chumash.   Pp. 760. 5  Ã‚   "Capital Punishment 1996".   Bureau of Justice Statistics Bulletin.   December 1997.   Pp. 3.         

Studying: Then and Now

Studying: Then and Now One June day, I staggered into a high school classroom to take my final exam in United States History IV. I had made my usual desperate effort to cram the night before, with the usual dismal results—I had gotten only to page 75 of a 400-page textbook. My study habits in high school, obviously, were a mess, but in college, I've made an attempt to reform my note-taking, studying, and test-taking skills. The first thing I tried to improve in college was note-taking. I took notes in high school classes but I often lost interest as compared to my note- taking at college.Note taking in high school classes often began with doodling, drawing Martians, or seeing what my signature would look like if I married the guy in the second row. Now, however, I try not to let my mind wander, and I pull my thoughts back into focus when they begin to go fuzzy. In high school, my notes often looked like something written in Arabic. In college, I've learned to use a semi-print writing style that makes my notes understandable. When I would look over my high school notes, I couldn't understand them.There would be a word like â€Å"Reconstruction,† then a big blank, then the word â€Å"important. † Weeks later, I had no idea what reconstruction was or why it was important. I've since learned to write down connecting ideas, even if I have to take the time to do it after class. Taking notes is one thing I've really learned to do better since high school days. Another area that I needed to concentrate on was my method of studying. Ordinary studying during the term is another area in which I've made changes. In high school, I let reading assignments go.I told myself that I'd have no trouble catching up on 200 pages during a 15-minute ride to school. College courses have taught me to keep pace with the work. Otherwise, I feel as though I'm sinking into a quicksand of unread material. When I finally read the high school assignment, my eyes would run over the words, but my brain would be plotting how to get the car for Saturday night. Now, I use several techniques that force me to really concentrate on my reading. I also changed the way of study for taking testsIn addition to learning how to cope with daily work, I've also learned to handle study sessions for big tests. My all-night study sessions in high school were experiments in self-torture. Around 2:00 A. M. , my mind, like a soaked sponge, simply stopped absorbing things. Now, I space out exam study sessions over several days. That way, the night before can be devoted to an overall review rather than raw memorizing. Most important, though, I've changed my attitude toward tests. In high school, I thought tests were mysterious things with completely unpredictable questions.Now, I ask instructors about the kinds of questions that will be on the exam, and I try to â€Å"psych out† the areas or facts instructors are likely to ask about. These practices really work, and f or me they've taken much of the fear and mystery out of tests. Since I've reformed, note-taking and studying are not as tough as they once were, and I am beginning to reap the benefits. As time goes on, my college test sheets are going to look much different from the red-marked tests of my high school days. Outline Introduction:Thesis Statement: My study habits in high-school, obviously were a mess, but in college, I’ve made an attempt to reform my note-taking, studying and test-taking skills. Topic sentence 1: I took notes in high school classes but I often lost interest as compared to my note- taking at college 1. Interest 2. Note writing 3. Connection Topic Sentence 2: Ordinary studying during the term is another area in which I've made changes. 1. Pace 2. Concentration Topic Sentence 3: In addition to learning how to cope with daily work, I've also learned to handle study sessions for big tests. 1. Spacing 2. Attitude Conclusion

Horatio Alger’s “Ragged Dick” Essay

In the story of â€Å"Ragged Dick†, Horatio Alger tells an inspirational story portraying a hero, Dick, to be the embodiment of individual opportunity in American culture. Dick gains mobility up the socio ­economic ladder through his good virtue and dedication to higher education. Dick is an honest young â€Å"black ­boot† with a second ­rate shared apartment and low vernacular. However, Dick is generous and industrious, while keeping a frugal stance as to know the value of a dollar. while en route of finding new work, a young boy falls into the east river, and the father swears great rewards to the rescuer. Dick, an excellent swimmer, dives off a ferry and saves the boy, without hearing of any reward. The father, a wealthy industrialist himself, rewards Dick by giving him a well ­paying job as a clerk at his office. Dick, now realizing his potential, has allowed himself a new name with his new career, signifying his upward climb on the ladder claiming that he i s finally, â€Å"cut off from the old vagabond life which he hoped never to resume† and sealing his grip upon the American Dream. Alger’s â€Å"rags to riches† story contains valuable tools that can be used to motivate a person’s social psychology, it’s myths can be unrealistic which can lead a person to believe a dream that could be impossible to obtain. The example of valor, hard work, and initiative are concrete tools for one’s toolbox, whereas relying only on gallantry can only go so far in our socio ­economic world. First, you could just take a look into the professions throughout our economy. Art, literature, and education are thrown on the back burner as business degrees are the #1 funded, and sought after, sectors.

37990) of May 2009 The WritePass Journal

The Intel infringement case (Comp/c-3/37990) of May 2009 Introduction The Intel infringement case (Comp/c-3/37990) of May 2009 IntroductionReferencesRelated Introduction Within the context of this given case, we aim to examine the background of the Intel infringement case reference Comp/c-3/37990 Intel of 13 May 2009, Intel are held responsible for infringing Article 83 of the EC Treaty where it has been found guilty of abusing its dominant market position on the x86 central processing unit (CPU) market by awarding rebates. We shall consider the basis on which the Decision Commission has made this decision to fine Intel and what evidence contributes towards this investigation. In addition to this, we will also be examining whether the decision taken was justified and if it had any kind of positive outcome on the consumers. If we consider the guidanc on the Commission enforcement priorities in implementing Article 82 on the EC Treaty to abusive exlusionary conduct by dominant undertaking. According to the Article 82 of Treaty that clearly outlines the EC Article 82 forbids any kind of abuse of a dominant position in the market. This goes hand in hand with the case-law where it is considered illegal for an undertaking to be in a dominant position and that such a dominant position is entitled to compete purely on basis of their hard work and merits. However, it should be noted that the undertaking concerned as a special responsibility forbidding its behaviour to diminish authentic deformed competition on the common market. It should be noted that Article 82 is considered as the legal fundamental for a critical element of competition policy and its effective enforcement that helps market operate more efficiently and effectively for the advantage of businesses and its consumers. It (Article 82) outlines the enforcement priorities that will guide the Commissions action in implementing Article 82 to exclusionary conduct by dominant undertakings. In addition to that, it attempts to offer a greater deal of accuracy and speculation in relation to the general framework of evaluation that the Commission recruits in determining whether it should pursue cases that relate to the various kinds of exclusionary conduct and to help undertakings better assess whether specific behaviour is likely to result in intervention by the Commission under Article 82. According to the application of Article 82 to exclusionary conduct by dominant undertakings, the Commission will emphasise on the kinds of behaviour that are most hazardous to consumers. It can be noted that even though it is the customer who is most likely to take advantage from the stiff competition, as it results in lower prices, good quality and a diverse choice of new enhanced services and goods. It is the duty of the Commission to instruct the enforcement to make sure the market operates in the precise manner, also making sure consumers take advantage from the efficiency and productivity that results from effective competition between under-takings. If consumers are excessively charged a high price or influencing their behaviour that under-estimates the efforts to accomplish a combined internal market that is considered to be liable of infringing Article 82. In regards to implementing the general enforcement fundamentals and rules set out in the Commission, it will take into account the specific facts and circumstances for every individual case. [Ref 1] Let us consider the background of the Intel case, Intel has a reputation for specialising in manufacturing microprocessors (CPUs) and chipsets for user personal computers. This is registered proprietor of well known brand names, such as: Pentium and Celeron. The Intel case is a perfect example of how cruelly and sensibly a corporation can take an advantage of its leading dominant position in the market. This case clearly outlines the inherent differences between the monopoly compared by intellectual property rights and the Treaty competition rules that forbids any form of abuse of dominant position. Intel has cleverly registered numerous thousands patents to safeguard its creative inventions and it is impossible in a pragmatic sense for its rivals to know in advance whether or not their products may read on Intels patents. Interestingly, Intel was found guilty of infringing its dominant position in relation to VIA, which is considered as one of Intels direct rivals in both the chipsets and CPU markets. As VIA was in need of the various components due to the interoperability, also due to the critical requirement for compatibility with Microsoft operations software. In order to make this operate, VIA required a licence from Intel that would allow them to use its patents in the design and manufacture of its chipsets which would let them communicate with Intels microprocessors. In addition to this, VIA also was in need of a licence in relation to its supply of CPUs so that they are completely Windows compaitable. It should be noted from the year 1998 to the year 2000, both the parties had a reciprocal chipset licencing agreement. By December 2000, Intel launched its latest Pentium 4 processor in the market, simultaneously that VIA would require a licence. A new licence was therefore by Intel on non-reciprocal conditions. Furthermore, such a proposed agreement envisaged an asymmetrical licenced that would entitle Intel to unlimited use of all the VIA patents and technology but VIA would only be able to acquire a licence to use Intels technology to manufacture and sell only specific chipsets. In addition to this, it even proposed a market division which would limit the VIA licence to the manufacture of chipsets for use with Pentium 4 processors, however it could not be used in conjunction with any enhanced versions of that same processor. According to VIA, Intel was infringin (September 2001) Article 82 of the EC Treaty and Chapter II of the Competition Act 1998 and it is not entitled to relief in circumstances where this would compel VIA to enter into a licence agreement consisting of illegal terms and conditions. In regards to the CPU Action, VIA outlined the two key competition law defences,   these consist of Intels refusal to licence its Pentium 4 technology which is considered as a violation and abuse of its dominant position in the CPU market. Secondly, Intels refusal to licence its prospective rights was abusive primarily because these rights related to technology that was the industry standard and which was significant in order for its rivals to have access to the CPU market. The refusal would eliminate competition from VIA and protect VIA from marketing valuable new products ( the essential facilities defence). It cannot be denied that the case is indeed very complex in its structure and nature , it consisted of a thorough and comprehensive investigation that was taken by the Commission. Whether Intel was accountable for abusing its dominance in the market by imposing a licencing policy for exploiting and enforcing its large portfolio of patent rights is evident from the various names that were included in this long list of names who complained of Intels abuse of power. It can be observed that within the Intel case, there are obvious signs of conditional rebates where they were bestowed to consumers, rewarding them for a specific kind of purchasing behaviour. Furthermore, such rebates within a dominant undertaking can have an actual or prospective pledge effects that are similar to exclusive purchasing contract. Intel was adamant to refuse granting of a licence on any kind of reasonable conditions, this clearly demonstrates its abuse of its dominantnposition in the CPU and chipset markets. Due to the patents being the industry standard it was impossible for chipset manufacturers to enter the market unless they were able to make use of Intels gateway technology. Interestingly when multi-product rebates take place, it is purely considered as anti-competitive, this is what exactly Intel did, it tried to do so on a tying market if it is a huge market that equally efficiently provides some of the key components however they cannot compete against the discounted bundle. Why is the CPU so much of an importance in the Intel case? This is primarly because the CPU is considered as an essential component of a computer, in regards to the actual performance and cost of the system. Furthermore, the manufacturing process of the CPU requires high technology and expensive facilities. The CPU is segmented into two sub-categories: CPUs of the x86 architecture and CPUs of a non-x86 architecture. The x86 architecture is a standard designed by Intel for its CPU. It can operate on both operating systems (Windows and Linux). According to the Commissions comprehensive investigation in the x86 CPUs, the relevant product market was not under the market of x86 CPUs. It can be noted that the 10 year period that has been considered and included by the Decision Commission   (1997-2007), Intel was seen to be continuously in a leading position, in terms of its market shares which were excessive by 70%. In addition to this, there were important obstacles to entry and development present in the x86 CPU market. Intel is a powerful and reputable brand, it saw a rise in its brand reputation due to product differentiation that contributed as an obstacle or hindrence to entry. The recognised high level of obstacles to entry and development are constant with the observed market structure, where all the leading rivals to Intel, apart from AMD left the market or they lacked some kind of importance. Furthermore, it can be observed that from October 2002 to December 2007,   according to the Decision, Intels market shares and obstacles to entry and development, Intel held a dominant position in the market. In terms of the condition rebates offered by Intel, it awarded major OEMs rebates that were conditioned on these OEM purchasing all or most of their supply requirements; this entails numerous brand who were offered these rebates. Dell was offered rebates for three years   December 2002- December 2005) that conditioned Dells purchasing exclusively Intel CPUs. With regards to the payments and rebates Intel offerd a major OEMs and MSH which are seen with context of the growing fierce compeition threat that AMD portrayed. With this regard, the Decisions demonstrated that OEMs, IT managers and Intel considered that AMD products had numerous positive innovative factors and they were considered a viable option to those of Intel. In essence, it can be agreed that the conditions of the case-law for detecting prospective abuse were evidently found, the Decision also conducted an economic analysis of the capability of the rebates to foreclose a rival that would be efficient as Intel, albeit not dominant. According to the found evidece collated by the Commission, it led to the conclusion that Intels conditional rebates and payment induced sincerity of key OEMs and of a major retailer, the effects of which were complementary in that they most importantly diminished rivals ability to compete on the merits of their x86 CPUs. Furthermore it can be added that Intels anti-competition conduct thereby resulted in a decrease of consumer choice and in lower incentives to innovate. Intel believed it did not wrong, it clearly defended the rebates and it stated in the two different kinds of arguments, that it wanted to introduce a rebate that would allow them to respond to price competition from its rivals and therefore it met stiff competition. Secondly, by using the rebate, it adopted a vis-a-vis every individual OEM was considered as significant, in order to accomplish significant efficiencies that were pertinent to the CPU industry. Intel carried on debating there were four different kinds of efficiencies that were accomplished by any exclusivity requirements of its rebates and production efficiencies and risk sharing and marketing efficiencies. According to the findings by the Commission, Intels debates relating to goal justification are flawed as they relate more generally to behaviour to which the Commission did not report (i.e.discounting of rebates) and not to conduct to which the Commission did object ( conditions relationg to rebates) and non of the efficiency defences offered an appropriate justification/ valid explanation for the behaviour questioned. It can be concluded that as a whole that the conditional rebats granted by Intel to Dell, HP, MSH and NEC collectively point at the abuse of a dominant position under Article 82 of the Treaty and Article 54 of the agreement. In addition to this, the individual abuses are also considered as part of a single strategy focused at foreclosing AMD.   Therefore the individual abuses form a part of a single infringement of Article 82 of the EC Treaty. In addition the Decision states that Intel practices were implemented collectively at two tiers of the distribution chain or cycle that can be viewed in the context of the rapidly growing competitive threat that are portrayed by AMD. Intel wanted to destroy the ability of AMD to compete at the same scale which would then result in making AMD weaker and be unable to match the same merits and standards as that of Intel, therefore, deliberately preventing them from selecting non-Intel based compueters on the merits. (i.e. quality and price of CPUs). The Decision determines that Intel has certainly infringed Article 82 of the Treaty and Article 54 of the EEA Agreement by getting involved in a single and consistent infringement of Article 82 of the Treaty and Article 54 of the EEA Agreement from October 2002- December 2002 by imposing a strategy targeted at foreclosing its rivals from the x86 CPU market. Intel was issued with a legal notice refraining it from any act or engaging in any activity that has the same or similar effect of this kind. It can   be concluded that the decision taken by the Decision Commission is certainly justified and even though consumers may have benefited from the decision, it was much more important for Intel to realise its mistake in abusing its dominant position in the market. References Communication from the Commission - Guidance on the Commissions enforcement priorities in applying Article 82 of the EC Treaty to abusive exclusionary conduct by dominant undertakings (Text with EEA relevance. Retrieved 8th April, 2011. From:http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=CELEX:52009XC0224(01):EN:NOT Howard, A (2003). Intel v VIA. Retrieved 9th April, 2011. From:monckton.com/docs/library/Intel%20v%20VIA%20Casenote.pdf Summary of Commission Decision of 13 May 2009 relating to a proceeding under Article 82 of the EC Treaty and Article 54 of the EEA Agreement (Case COMP/C-3/37990 – Intel). Retrieved 9th April, 2011. From:http://ec.europa.eu/competition/sectors/ICT/intel_summary_decision_en.pdf

Kenyetta Douglas Essays - Self-defense, Free Essays, Term Papers

Kenyetta Douglas Essays - Self-defense, Free Essays, Term Papers Kenyetta Douglas AP Lang and Composition Ayau 14 December 2016 Stand Your Ground Laws Are Failing In a problematic situation, such as an assailant waving a gun at a victim, the victim has the right to protect themselves if they are feeling threatened. How would someone respond if an assailant is waving a gun using a threatening tone? Someone might respond by trying to avoid the situation or by retreating, or the person will take his chance and try to protect his life. This scenario is covered under the Stand Your Ground or SYG law. The question that troubles people is the effectiveness of the Stand Your Ground law. The Stand Your Ground has flaws which affect the validity of the law and shows no sign of protecting the human race. The flaws include, the law protects the guilty, the law is vague, and it gives the right to kill. The Stand Your Ground law states that person has the right to use deadly force if needed and if there is an retreat option the person can do so but they do not have to (Hundley et al, 2) According to Hundley and other writers, the law also addresses that if the victim cannot retreat then he or she may use any force necessary to protect himself.(2) The law first emerged after 9/11 in 2001 when the public safety of society was diminished. The law was later changed in 2005 by Jeb Bush, but it did not have any more detailed specifications than the expansion to the castle doctrine( the law that gives people the right to protect their home and their valuables) (Cohen 3). There are a total of 22 of states who have the Stand Your Ground law, including states Kentucky,Florida, Texas , and Pennsylvania. The statistics show that the SYG law has resulted in an increase in firearm homicides because the assailant believes he can get off unprosecuted in a court. According Walkens duri ng "2007-2009 over 4,900 people in the U.S. died from unintentional shootings"(Walkens 20) Walkens also addresses that the U.S. has the highest gun deaths out of 36 of the wealthiest nations (21). One of the reasons the SYG law is flawed is, because it claims it protect people from bodily harm when they are letting the guilty go free while the innocent person was harmed. Many people can elude the law by simply calling out "self defense" when an victim is dead. In 2004 eight homicides were deemed justifiable as of in the court(Cloud 3). SYG laws allow for people to premeditate what they are going to do to the victim they despise, resulting in usually the death of the victim. No one can prove otherwise that the assailant had attacked the victim making the law seem unfair(National Task Force 30). The jurors' and the judge's judgment of the assailant's plea is debated because the case is biased to the assailant's recollection of the altercation that happened earlier. Statistics show that about 70% of people who claim self defense under the SYG law goes free (Hundley et al., 1). Cloud found out that in 2010,about 5 years after the SYG law was enacted the number of justifiab le homicides increased to 40 from eight homicides (3). In addition to protecting the guilty, the jury is obliged to think on a level where they see that one person was saved from an altercation rather than two casualties(Lave 21-22). The SYG law is strongly based on protection of a life resulting in the bias to be put on the jury in the trial. The bias presented through the SYG law is that the jury is likely to believe the assailant since there is no one to contradict his statement making the judge biased. Another flaw in the SYG law is that the use of deadly force has many factors in determining the force needed to protect someone's life. For example if someone was fighting using physical force then there is no reason for the victim to bring out a gun since the force is minimum. The first factor is the correspondence of the threat to the victim. So in any case where the assailant is trying to just

Brain Tumour Glioblastoma Multiforme Problem Health And Social Care Essay

GBM normally affects people who older than 50 old ages old although the disease can happen in patients from all age group [ 2,25,28 ] . Patients suffer ictus, concern, ocular perturbation and sometimes personality alterations which can do great emotional hurt [ 25,30,31 ] . The average endurance of GBM patients is hapless, with about 12 to 14 months [ 7 ] . At this minute, the exact causes of GBM still remain vague to the scientists. Figure 1 GBM tumor is normally found in frontal and temporal lobe. Beginning: hypertext transfer protocol: //ebsco.smartimagebase.com/brain-tumor/view-item? ItemID=4027 Accumulative Word Count: 131 Possible Treatments Surgery Surgery is normally the initial measure to handle GBM by taking every bit much tumor as possible. It is non healing but aims to cut down the tumor ‘s size every bit much as possible so that other therapies right after the surgery can be more effectual. Furthermore, surgical resection Acts of the Apostless to alleviate hydrops by debulking tumor every bit good as being a alleviative intervention for neurologic symptoms such as ictus activity [ 7 ] . The surgery includes standard surgical process craniotomy which removes a subdivision of skull to expose the encephalon underneath in order to unclutter the tumor. Besides, patients may choose to undergo optical maser microsurgery or supersonic aspiration to hold their tumors removed. 2 1 3 4 Figure 2 Craniotomy hypertext transfer protocol: //ebsco.smartimagebase.com/surgical-craniotomy/view-item? ItemID=40345 Accumulative Word Count: 242 Radiation Therapy Normally, radiation therapy ( RT ) is administered instantly after surgery. It works chiefly by damaging the Deoxyribonucleic acid of tumor cells, killing any residuary tumor cells after surgical remotion of the tumour [ 3-6,32 ] . A research has shown that the average endurance clip has increased from 17 hebdomads ( treated with conventional attention ) to 37.5 hebdomads when the GBM patients were treated with RT entirely while combination of BNCU ( carmustine ) and RT produced a 40.5 hebdomad average endurance [ 11 ] . Table 1 Randomized surveies of post-operative radiation compared with no radiation therapy in malignant gliomaa [ 23 ] Study [ Ref. ] Study group Radiation dose Gy/ no. of fraction No. of patients randomized ( analyzed ) Median endurance ( hebdomads ) Overall endurance P value Shapiro et al. , 1976 [ 62 ] Connecticut RT + CT – 60 16 ( 16 ) 17 ( 17 ) 30 44.5 NR Not important Andersen, 1978 [ 1 ] Surgery entirely RT – 45/25 57 ( 57 ) 51 ( 51 ) 15b 23b †¹0.005 Survival at 6 months Walker et al. , 1978 [ 78 ] vitamin D Surgery entirely RT – 50-60/25-35 42 ( 31 ) 93 ( 68 ) 14c 36c 0.001 Walker et al. , 1980 [ 79 ] vitamin D Connecticut RT – 60/30-35 111 ( 111 ) 118 ( 118 ) 31 37 0.003 Kristiansen et al. , 1981 [ 36 ] vitamin D Surgery entirely RT + / – Connecticut – 45/25 38 ( 38 ) 80 ( 80 ) 23 47 NR Significant Sandberg-Wollheim et al. , 1991 [ 60 ] Connecticut RT + CT – 58/27 87 ( 87 ) 84 ( 84 ) 42 62 0.028 a CT, chemotherapy ; NR, non reported ; RT, radiation therapy. B Calculated from survival curve. 500 Multi-arm survey that included a radiation plus chemotherapy arm. For both surveies by Walker et al. , merely information from the radiation entirely arm are shown in Table 2. Kristiansen et Al. reported combined informations from the radiation entirely arm and the radiation plus chemotherapy arm. In each of these surveies, there was a important survival benefit favouring radiation plus chemotherapy compared with no radiation therapy but no important difference in endurance between radiation entirely and radiation plus chemotherapy ( informations non shown ) . degree Celsiuss Merely consequences for the evaluable patients were reported ( 31 patients in the surgery entirely arm and 68 patients in the RT arm ) . Accumulative Word Count: 329 RT is normally administered through external beam radiation but internal radiation called Brachytherapy is besides possible. Each manner differs in how the radiation beginnings are delivered to the tumour [ 4-6,32 ] . Using IMRT ( Intensity-Modulated Radiation Therapy ) , a machine such as additive gas pedal delivers precise high-energy radiation doses ( eg: X raies ) to the tumor accurately and kills the affected cells [ 6,33 ] . Most patients will have the intervention for five to seven hebdomads [ 6,32,34 ] . Typically, around 6000 to 6500 units of radiation are delivered over seven hebdomads [ 6 ] . In contrast, brachytherapy topographic point the radiation beginnings every bit near as possible to the targeted cells in shorter clip comparison to external radiation. It consists of radioactive implants in the signifier of catheters or seeds which has impermanent radioactive beginnings in the tumor [ 8 ] . Figure 3 Brachythrapy hypertext transfer protocol: //ebsco.smartimagebase.com/brachytherapy/view-item? ItemID=24923 Besides, stereotactic radiosurgery, a noninvasive method of presenting an intense and focused dosage of radiation to a little country can be used for GBM excessively. Treatment dose is individualized but the typical dosage is about 2500 units of radiation per intervention [ 6 ] . Other signifiers of radiation intervention such as installing of inflatable balloon incorporating liquid radiation or interpolation of monoclonal antibodies tagged with radioactive substances may be used [ 8 ] . Accumulative Word Count: 519 Chemotherapy Chemotherapy may be given after surgical resection and radiation. In this therapy, chemotherapeutic drugs play an of import function in impacting retroflexing cells by damaging the Deoxyribonucleic acid of these cells. The most normally used drugs are carmustine ( BNCU ) , lomustine ( CCNU ) , temozolomide ( Temodar ) and procarbazine. They are classified as alkylating agents which are DNA-damaging drugs. These drugs alkylate the Deoxyribonucleic acid in the tumor cells, doing the dual strands to be cross-linked to each other in an inappropriate manner. This thereby, blocks DNA reproduction and bit by bit leads to cell decease [ 4,5,8 ] . Soon, Gliadel Wafer – a biodegradable wafer soaked with BNCU is prevailing among the interventions. This is done by engrafting wafers in the pit after surgical remotion of the tumor. The wafers so easy let go of high concentrations of BCNU straight into the tumour country over a period of 2-3 hebdomads. Gliadel does non supply a remedy for GBM but is believed to be capable of protracting endurance. Apart from that, temozolomide is more frequently administered orally on monthly rhythm for 6-12 months after surgery and radiation as a care therapy [ 6,8,28,29 ] . Traditional chemotherapy drugs can be effectual, but most of them do non separate between healthy and tumour cells, thereby forestalling the disposal of high doses to kill the unnatural cells. What is more, their generalised toxicity can do terrible side effects. Targeted therapy drugs like Avastin ( bevacizumab ) are more precise than some chemotherapy drugs and tend to hold fewer side effects. It has been approved by FDA in 2009 as a new biologic drug to handle GBM. Avastin acts chiefly as an angiogenesis inhibitors by decelerating the growing of new blood vass environing the tumor. It selectively blocks VEGF to suppress the activation of VEGF receptors tyrosine kinases VEGFR1 and VEGFR2 [ 13-15 ] . There are some surveies to turn out that approximately 20-30 % patients with GBM do react to the drugs [ 27 ] . Accumulative Word Count: 823 A Graph 1 Kaplan-Meier endurance curves for patients treated with steroids and ( A ) resective surgery merely, ( B ) resective surgery and radiation therapy and ( C ) resective surgery, radiation therapy and chemotherapy. [ 12 ] Bacillus C Accumulative Word Count: 848 Social and Economic Deductions The trouble to digest with the side effects of the medicines such as sleepiness and hair loss may do GBM patients to experience down and hurt. They may be easy frustrated by concerns they suffer often or experience suffering and hopeless after the diagnosing [ 34 ] . This could take to serious societal impact and would worry the people around them. Furthermore, most of the patients find it hard to return to work due to decrease in productiveness. A study has shown that with 91 % patients were employed before diagnosing, merely 33 % of them continue working after interventions. While health professionals who were still working experience employment alterations such as taking leave of absence to be with their loved 1s for interventions or taking on extra paid work might experience stressed and have to fight difficult to get by with the tough life [ 9 ] . In order to run a normal life, patients require undergo a plentifulness of interventions including hospitalization after surgery which would do great fiscal load. It is estimated that cost of GBM interventions ranged from ˆ10 893 to ˆ125 275 [ 22 ] . Trouble of obtaining insurance makes the status even worse. Drugs that are necessary for GBM interventions are expensive and are normally administered over long period of clip. All this becomes a beginning of depression which affects non merely the patients but their households and friends [ 9 ] . The return of GBM after conventional therapy is inevitable. This so creates unstoppable medical crisis every bit good as fiscal hurt to the patients and their households. Accumulative Word Count: 1084 Benefits and Hazards I believe a combination of surgery, radiation therapy and chemotherapy is the most effectual intervention for GBM presently. In malice of its forecast has remained hapless for the last few decennaries, patients do acquire better after adhering to this standard therapy. Although GBM can non be cured, the patients had have their survival clip prolonged, acquiring a opportunity to pass their last few months with their loved 1s in a meaningful manner [ 34 ] . Nevertheless, the interventions do enforce distressing side effects to human wellness. Despite killing tumour cells, alkylating agents used are considered toxic, ensuing in suppression or lowering of blood counts. They have been associated with important sickness, hair loss, weariness and sterility [ 5 ] . High doses of BNCU may take to damage and marking of the lungs while procarbazine can do raging concern, purging and numbness. Hence, doses of drugs administered have to be carefully monitored by doctor to avoid taking to unwanted effects. Recently invented drugs temozolomide, has comparatively mild side effects but they are still inevitable [ 6 ] . Meanwhile, hazard of developing acute leukaemia old ages subsequently is increased when patients are exposed to alkylating agents [ 5 ] . Avastin, a freshly developed drug, provides a more effectual therapy for GBM. However, it potentially creates fatal toxicity, doing the late closed surgical lesion interruptions down. Some claim that the development of toxicity by avastin may shorten endurance in some patients when it is added to radiotherapy and temozolomide. Thus, researches on the effectivity and safety of use of avastin should be carried on continually until desirable consequences are obtained [ 20 ] . In add-on, the return of the tumor is ineluctable, with the average endurance rate of patients who relapse runing from 3-6 months despite aggressive intervention [ 10 ] . Patients may develop the feeling that the medicines are useless or may give up because of the intolerable side effects and the unstoppable backsliding of disease. This will take to non-adherence to therapy and increase the hazard of mortality. However, in my sentiment, the multimodal treatments I discuss above are still considered the best solution for GBM as they outweigh the hazards by protracting the patients ‘ survival clip. Accumulative Word Count: 1432 Alternate Treatments Gene therapy Another promising attack of handling GBM is cistron therapy. Herpes simplex virus thymidine kinase/ganciclovir ( HSV-tk/GCV ) has evolved as a cytotoxic cistron therapy. In this instance, recombinant adenoviral vectors are used to give favorable consequences. Adenoviral HSV-tk ( AdHSV-tk ) is able to assail the residuary dividing tumour cells while go forthing the non-dividing nerve cells unharmed. What ‘s more, it can destruct the malignant neoplastic disease cells through bystander- consequence [ 19 ] . HSV-tk first converts GCV to GCV-monophosphate [ 16,17 ] . Then, cellular kinases farther convert this merchandise to GCV-triphosphate which is a hapless substrate for uninterrupted DNA elongation due to the lacking of 3 ‘ hydroxyl group that is needed to organize phosphodiester bond in chain-elongation-reaction. Ultimately, nonfunctional Deoxyribonucleic acid fragments are formed, triping programmed cell death in malignant neoplastic disease cells [ 18 ] . Nowadays, AdH SV-tk /GCV is going preferred comparisons to conventional radiation therapy and chemotherapy due to its fewer inauspicious effects. Figure 4 The rule of HSV-tk/GCV cistron therapy. hypertext transfer protocol: //www.gtmb.org/VOL4A/GTMBVOL4AHTML/23_Adachi_files/image001.gif Accumulative Word Count: 1575 Table 2 Surveies by Sandmair et Al. and Immonen et Al. demo a singular protraction of endurance in patients treated with AdHSV-tk [ 19 ] . Patients Vector Phase Gene Transfer Method Adverse Effectss Survival ( Months ) Response Brain Tumour Glioblastoma Multiforme Problem Health And Social Care Essay GBM normally affects people who older than 50 old ages old although the disease can happen in patients from all age group [ 2,25,28 ] . Patients suffer ictus, concern, ocular perturbation and sometimes personality alterations which can do great emotional hurt [ 25,30,31 ] . The average endurance of GBM patients is hapless, with about 12 to 14 months [ 7 ] . At this minute, the exact causes of GBM still remain vague to the scientists. Figure 1 GBM tumor is normally found in frontal and temporal lobe. Beginning: hypertext transfer protocol: //ebsco.smartimagebase.com/brain-tumor/view-item? ItemID=4027 Accumulative Word Count: 131 Possible Treatments Surgery Surgery is normally the initial measure to handle GBM by taking every bit much tumor as possible. It is non healing but aims to cut down the tumor ‘s size every bit much as possible so that other therapies right after the surgery can be more effectual. Furthermore, surgical resection Acts of the Apostless to alleviate hydrops by debulking tumor every bit good as being a alleviative intervention for neurologic symptoms such as ictus activity [ 7 ] . The surgery includes standard surgical process craniotomy which removes a subdivision of skull to expose the encephalon underneath in order to unclutter the tumor. Besides, patients may choose to undergo optical maser microsurgery or supersonic aspiration to hold their tumors removed. 2 1 3 4 Figure 2 Craniotomy hypertext transfer protocol: //ebsco.smartimagebase.com/surgical-craniotomy/view-item? ItemID=40345 Accumulative Word Count: 242 Radiation Therapy Normally, radiation therapy ( RT ) is administered instantly after surgery. It works chiefly by damaging the Deoxyribonucleic acid of tumor cells, killing any residuary tumor cells after surgical remotion of the tumour [ 3-6,32 ] . A research has shown that the average endurance clip has increased from 17 hebdomads ( treated with conventional attention ) to 37.5 hebdomads when the GBM patients were treated with RT entirely while combination of BNCU ( carmustine ) and RT produced a 40.5 hebdomad average endurance [ 11 ] . Table 1 Randomized surveies of post-operative radiation compared with no radiation therapy in malignant gliomaa [ 23 ] Study [ Ref. ] Study group Radiation dose Gy/ no. of fraction No. of patients randomized ( analyzed ) Median endurance ( hebdomads ) Overall endurance P value Shapiro et al. , 1976 [ 62 ] Connecticut RT + CT – 60 16 ( 16 ) 17 ( 17 ) 30 44.5 NR Not important Andersen, 1978 [ 1 ] Surgery entirely RT – 45/25 57 ( 57 ) 51 ( 51 ) 15b 23b †¹0.005 Survival at 6 months Walker et al. , 1978 [ 78 ] vitamin D Surgery entirely RT – 50-60/25-35 42 ( 31 ) 93 ( 68 ) 14c 36c 0.001 Walker et al. , 1980 [ 79 ] vitamin D Connecticut RT – 60/30-35 111 ( 111 ) 118 ( 118 ) 31 37 0.003 Kristiansen et al. , 1981 [ 36 ] vitamin D Surgery entirely RT + / – Connecticut – 45/25 38 ( 38 ) 80 ( 80 ) 23 47 NR Significant Sandberg-Wollheim et al. , 1991 [ 60 ] Connecticut RT + CT – 58/27 87 ( 87 ) 84 ( 84 ) 42 62 0.028 a CT, chemotherapy ; NR, non reported ; RT, radiation therapy. B Calculated from survival curve. 500 Multi-arm survey that included a radiation plus chemotherapy arm. For both surveies by Walker et al. , merely information from the radiation entirely arm are shown in Table 2. Kristiansen et Al. reported combined informations from the radiation entirely arm and the radiation plus chemotherapy arm. In each of these surveies, there was a important survival benefit favouring radiation plus chemotherapy compared with no radiation therapy but no important difference in endurance between radiation entirely and radiation plus chemotherapy ( informations non shown ) . degree Celsiuss Merely consequences for the evaluable patients were reported ( 31 patients in the surgery entirely arm and 68 patients in the RT arm ) . Accumulative Word Count: 329 RT is normally administered through external beam radiation but internal radiation called Brachytherapy is besides possible. Each manner differs in how the radiation beginnings are delivered to the tumour [ 4-6,32 ] . Using IMRT ( Intensity-Modulated Radiation Therapy ) , a machine such as additive gas pedal delivers precise high-energy radiation doses ( eg: X raies ) to the tumor accurately and kills the affected cells [ 6,33 ] . Most patients will have the intervention for five to seven hebdomads [ 6,32,34 ] . Typically, around 6000 to 6500 units of radiation are delivered over seven hebdomads [ 6 ] . In contrast, brachytherapy topographic point the radiation beginnings every bit near as possible to the targeted cells in shorter clip comparison to external radiation. It consists of radioactive implants in the signifier of catheters or seeds which has impermanent radioactive beginnings in the tumor [ 8 ] . Figure 3 Brachythrapy hypertext transfer protocol: //ebsco.smartimagebase.com/brachytherapy/view-item? ItemID=24923 Besides, stereotactic radiosurgery, a noninvasive method of presenting an intense and focused dosage of radiation to a little country can be used for GBM excessively. Treatment dose is individualized but the typical dosage is about 2500 units of radiation per intervention [ 6 ] . Other signifiers of radiation intervention such as installing of inflatable balloon incorporating liquid radiation or interpolation of monoclonal antibodies tagged with radioactive substances may be used [ 8 ] . Accumulative Word Count: 519 Chemotherapy Chemotherapy may be given after surgical resection and radiation. In this therapy, chemotherapeutic drugs play an of import function in impacting retroflexing cells by damaging the Deoxyribonucleic acid of these cells. The most normally used drugs are carmustine ( BNCU ) , lomustine ( CCNU ) , temozolomide ( Temodar ) and procarbazine. They are classified as alkylating agents which are DNA-damaging drugs. These drugs alkylate the Deoxyribonucleic acid in the tumor cells, doing the dual strands to be cross-linked to each other in an inappropriate manner. This thereby, blocks DNA reproduction and bit by bit leads to cell decease [ 4,5,8 ] . Soon, Gliadel Wafer – a biodegradable wafer soaked with BNCU is prevailing among the interventions. This is done by engrafting wafers in the pit after surgical remotion of the tumor. The wafers so easy let go of high concentrations of BCNU straight into the tumour country over a period of 2-3 hebdomads. Gliadel does non supply a remedy for GBM but is believed to be capable of protracting endurance. Apart from that, temozolomide is more frequently administered orally on monthly rhythm for 6-12 months after surgery and radiation as a care therapy [ 6,8,28,29 ] . Traditional chemotherapy drugs can be effectual, but most of them do non separate between healthy and tumour cells, thereby forestalling the disposal of high doses to kill the unnatural cells. What is more, their generalised toxicity can do terrible side effects. Targeted therapy drugs like Avastin ( bevacizumab ) are more precise than some chemotherapy drugs and tend to hold fewer side effects. It has been approved by FDA in 2009 as a new biologic drug to handle GBM. Avastin acts chiefly as an angiogenesis inhibitors by decelerating the growing of new blood vass environing the tumor. It selectively blocks VEGF to suppress the activation of VEGF receptors tyrosine kinases VEGFR1 and VEGFR2 [ 13-15 ] . There are some surveies to turn out that approximately 20-30 % patients with GBM do react to the drugs [ 27 ] . Accumulative Word Count: 823 A Graph 1 Kaplan-Meier endurance curves for patients treated with steroids and ( A ) resective surgery merely, ( B ) resective surgery and radiation therapy and ( C ) resective surgery, radiation therapy and chemotherapy. [ 12 ] Bacillus C Accumulative Word Count: 848 Social and Economic Deductions The trouble to digest with the side effects of the medicines such as sleepiness and hair loss may do GBM patients to experience down and hurt. They may be easy frustrated by concerns they suffer often or experience suffering and hopeless after the diagnosing [ 34 ] . This could take to serious societal impact and would worry the people around them. Furthermore, most of the patients find it hard to return to work due to decrease in productiveness. A study has shown that with 91 % patients were employed before diagnosing, merely 33 % of them continue working after interventions. While health professionals who were still working experience employment alterations such as taking leave of absence to be with their loved 1s for interventions or taking on extra paid work might experience stressed and have to fight difficult to get by with the tough life [ 9 ] . In order to run a normal life, patients require undergo a plentifulness of interventions including hospitalization after surgery which would do great fiscal load. It is estimated that cost of GBM interventions ranged from ˆ10 893 to ˆ125 275 [ 22 ] . Trouble of obtaining insurance makes the status even worse. Drugs that are necessary for GBM interventions are expensive and are normally administered over long period of clip. All this becomes a beginning of depression which affects non merely the patients but their households and friends [ 9 ] . The return of GBM after conventional therapy is inevitable. This so creates unstoppable medical crisis every bit good as fiscal hurt to the patients and their households. Accumulative Word Count: 1084 Benefits and Hazards I believe a combination of surgery, radiation therapy and chemotherapy is the most effectual intervention for GBM presently. In malice of its forecast has remained hapless for the last few decennaries, patients do acquire better after adhering to this standard therapy. Although GBM can non be cured, the patients had have their survival clip prolonged, acquiring a opportunity to pass their last few months with their loved 1s in a meaningful manner [ 34 ] . Nevertheless, the interventions do enforce distressing side effects to human wellness. Despite killing tumour cells, alkylating agents used are considered toxic, ensuing in suppression or lowering of blood counts. They have been associated with important sickness, hair loss, weariness and sterility [ 5 ] . High doses of BNCU may take to damage and marking of the lungs while procarbazine can do raging concern, purging and numbness. Hence, doses of drugs administered have to be carefully monitored by doctor to avoid taking to unwanted effects. Recently invented drugs temozolomide, has comparatively mild side effects but they are still inevitable [ 6 ] . Meanwhile, hazard of developing acute leukaemia old ages subsequently is increased when patients are exposed to alkylating agents [ 5 ] . Avastin, a freshly developed drug, provides a more effectual therapy for GBM. However, it potentially creates fatal toxicity, doing the late closed surgical lesion interruptions down. Some claim that the development of toxicity by avastin may shorten endurance in some patients when it is added to radiotherapy and temozolomide. Thus, researches on the effectivity and safety of use of avastin should be carried on continually until desirable consequences are obtained [ 20 ] . In add-on, the return of the tumor is ineluctable, with the average endurance rate of patients who relapse runing from 3-6 months despite aggressive intervention [ 10 ] . Patients may develop the feeling that the medicines are useless or may give up because of the intolerable side effects and the unstoppable backsliding of disease. This will take to non-adherence to therapy and increase the hazard of mortality. However, in my sentiment, the multimodal treatments I discuss above are still considered the best solution for GBM as they outweigh the hazards by protracting the patients ‘ survival clip. Accumulative Word Count: 1432 Alternate Treatments Gene therapy Another promising attack of handling GBM is cistron therapy. Herpes simplex virus thymidine kinase/ganciclovir ( HSV-tk/GCV ) has evolved as a cytotoxic cistron therapy. In this instance, recombinant adenoviral vectors are used to give favorable consequences. Adenoviral HSV-tk ( AdHSV-tk ) is able to assail the residuary dividing tumour cells while go forthing the non-dividing nerve cells unharmed. What ‘s more, it can destruct the malignant neoplastic disease cells through bystander- consequence [ 19 ] . HSV-tk first converts GCV to GCV-monophosphate [ 16,17 ] . Then, cellular kinases farther convert this merchandise to GCV-triphosphate which is a hapless substrate for uninterrupted DNA elongation due to the lacking of 3 ‘ hydroxyl group that is needed to organize phosphodiester bond in chain-elongation-reaction. Ultimately, nonfunctional Deoxyribonucleic acid fragments are formed, triping programmed cell death in malignant neoplastic disease cells [ 18 ] . Nowadays, AdH SV-tk /GCV is going preferred comparisons to conventional radiation therapy and chemotherapy due to its fewer inauspicious effects. Figure 4 The rule of HSV-tk/GCV cistron therapy. hypertext transfer protocol: //www.gtmb.org/VOL4A/GTMBVOL4AHTML/23_Adachi_files/image001.gif Accumulative Word Count: 1575 Table 2 Surveies by Sandmair et Al. and Immonen et Al. demo a singular protraction of endurance in patients treated with AdHSV-tk [ 19 ] . Patients Vector Phase Gene Transfer Method Adverse Effectss Survival ( Months ) Response

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Report - Essay Example There are recent examples of this mass socio-cultural shift: the arrest of the renowned â€Å"Queen of the Pacific,† Mexican drug lord Sandra Avila Beltran, and the portrayal of a brutal female drug kingpin by Salma Hayek in the soon-to-be-released Oliver Stone film Savages. Despite the unquestionably heavy feminine presence in the drug trade, the historically macho world of drug smuggling can still be said to have victimized women. Women, particularly in Latin American countries, have come to identify equality with access to commercial opportunity in the most lucrative business venture available to them: the drug trade. In this way, in their struggle for gender parity, women have wittingly become part of the same destructive cycle with which men have typically been associated. This may, in part, be driven by persistently high rates of violence against women in Latin America, with women seeking a measure of control amid the carnage (see graph, page 6). By asserting their femin inity, some achieve power but compromise their moral existence in what can best be characterized as a devil’s bargain. ... While this may once have been true, the burgeoning drug trade has carried women to power and international infamy on a scale heretofore unknown and unanticipated by many for whom females have always been the prototypical victims of the drug trade and the collateral damage it creates. New lifestyle, new opportunity This is not to argue that countless women are not thus victimized. But their increasing presence at the highest levels of some of the most powerful drug organizations indicates that women are susceptible to the same economic and psychological motivations that have previously been ascribed to men only. In his widely cited anthropological study of the Mexican drug trade, Hugh Campbell has ascertained that female drug smugglers enjoy â€Å"a pleasurable lifestyle and relative autonomy from men,† aggrandizing their power in the same violent and ruthless ways as men. Campbell examines a female subject he identifies as Zulema, whose pursuit of the high-risk, high-return li festyle is typical of the new breed of women in the trade. â€Å"Contrary to standard interpretations of women’s motivation for entry into drug smuggling, Zulema was initially attracted to crime, including drug-selling, by the opportunity it presented for adventure and revolt against bourgeois lifestyles† (antropologi, 2008). Such women have done more than simply reject poverty and a non-descript lifestyle; they seek the â€Å"high† that comes from a powerful adrenaline rush. There is an element of glamour to the drug underworld, and in a sense women have long been a part of the image it projects in mass culture. There is a long association between beauty and illicit activity. During Prohibition, bootleggers were famous for showing off beautiful female